Month: May 2020

Have you ever wondered why it takes so long for new medications to reach the mass market?  And What’s the best medical spa marketing idea that you can follow in order to promote your medical spa. Here are the answers to all your questions. 

The process to gain FDA drug approval has stringent criteria that all medications must meet before the product can be provided to the public at large.

There are four phases of human studies necessary for FDA drug approval for clinical use. The first phase or Phase 1- lasts an average of 1 year. At this point in the study 20-100, normal and healthy volunteers (who are free of problems that may contaminate the interpretation of data or alter the sensitivity of the drug) are studied. At this point in the process it is allowable to include those people with the problem that the drug is targeted to treat. This phase does not allow for the inclusion of some populations including children, women with childbearing potential, and seriously ill patients. Trials of the medication during this phase must be conducted on an in-patient basis. Researchers will be assessing any safety concerns with the medication in addition to determining appropriate dosages. Of those medications introduced 30% fail to make it to the next phase of review.

The next phase lasts approximately 2 years with 100 to 300 volunteers participating. Patients are evaluated for drug effectiveness and side effects. Participants should be free of serious disease (especially the liver, kidney, blood, or heart disease) and should not be receiving other treatment protocols. Women of childbearing age may be included in this phase if data regarding safety has been amassed and the FDA Animal reproduction guidelines have been completed. These participants must be actively guarding against pregnancy must be in place prior to starting the study. About 33% of drugs studied move on to Phase III.

Phase 3 of the process lasts 1 to 4 years with a study group of 1,000 – 3,000 volunteers. The objective of this phase is to verify the effectiveness and monitor adverse reactions from long term use. Patients in Phase II and III may be included if they concomitant diseases and therapy as they represent segments of the population who would receive the drug upon approval. Phase II and III are often combined to shorten the approval process on new medications. 25 % of these drugs move on the final approval or Phase IV. There is a 24 month New Drug Application process through the FDA before moving from Phase III to IV.

The fourth and final phase is the post-marketing phase. These are studies that take place after the drug’s final approval. The focus is on further evaluation of the drug’s safety and efficacy for various populations and broader use conditions aside from the original intended use.

Once these phases are complete the decision is made whether the drug is approved or not. Should the drug fail to be approved there is an appeal process available. Drugs are free to be marketed and distributed upon receipt of approval.

Have questions about green tea for dieters? Want to know what really works and what doesn’t? I’ve searched for the most frequently asked questions concerning green tea for dieters and have compiled the answers for the top 5. So, without further fuss, here they are:

1. How fast is it going to work? Truthfully? Not very fast. Expect to burn an extra 80 calories a day if you drink about 4 to 5 cups. That translates into roughly about 8 pounds a year for a person eating a 2000 calorie a day diet. Not really bad for just adding a great tasting drink to your daily fare. Of course, you can always loose a lot more weight by adding 20-30 minutes a day of exercise! (Did I really even have to say that?

2. How much do I have to drink for it to work? As I pointed out earlier, about 5 cups a day consumed will burn close to 80 extra calories. So, could drinking more increase calorie burn? Interestingly enough, no. Taiwanese researchers have proven that it’s not the amount you drink per day, but how long you drink it that effects weight loss. So drink 4-6 cups a day and continue to do so as a permanent part of your healthy lifestyle and you will see results.

3. How can I make it taste better without adding calories? A lot of people do not like the taste of green tea and consider it bitter. But, there are things you can do to improve the taste without adding unnecessary calories. The main thing is to let it steep no more than 3-4 minutes. The beneficial attributes are all released by this time and any more steeping deepens the bitter flavor. Add lemon or even lime. This cuts the bitterness and has shown to enhance the teas health benefits. Lastly, Splenda or stevia are both naturally derived, no-calorie sweeteners that may help make the taste more pleasing.

4. What is the best? When choosing, choose for taste and origin. For dieters, all types work the same. It all produces an effect in the body called thermogenesis (a heat generating action) that causes the extra calorie burn. Choose a tea that has organic origins (no pesticides used in the growing) and one that you like the taste of best. To enhance the fat burning effects some people even add certain herbs to their brew. So, as long as its pure, the best is your preference.

5. What about those diet products? Are they any better? Many diet products boast green tea as their main fat burning ingredient. However, there are problems. First, the diet companies tend to go for quantity, not quality, adding fillers to their products to add weight. This makes the product cheaper to produce, but reduces its effectiveness. Second, a lot of these diet products use chromium to make the appetite suppressing benefit that’s usually attributed to green tea, misleading the client to believe that green tea will make you less hungry. Thirdly, green tea itself has many more health benefits available to the drinker that don’t come in its chemically altered counterpart. In the end, the closer to its natural state, the better the benefits.

In conclusion, green tea will help you loose weight, but it must be combined with a healthy diet and exercise to see a big difference. Remember, to loose weight you simply must burn more calories than you take in. Plus, it has been shown to be good for the skin, digestion, fighting certain types of cancer and promoting a general state of well being. So, add some “green” to your diet. You’ll be glad you did!

Green tea is the perfect alternative that you can find in modern times to keep yourself in good shape with no extra flab for company which mostly makes you lazy and lethargic so take care to drink it after completing your day’s exercise and do read custom keto diet reviews online at regular intervals.

During the first few months after I moved to Alabama, one of my primary concerns was developing a sedentary lifestyle that would lead to overeating, weight gain, and eventually obesity. I had learned that Alabama ranks among the top states in the nation for obesity, and the last thing that I wanted was to become another statistic. Although I am not overweight, I decided that I would take better control of my health with the help of picături idealica and do the complete opposite of what I feared – I would make a permanent lifestyle change that would consist of eating healthier and working out regularly.

Not more than a couple of weeks after I chose self-empowerment over doom, a little help came my way. I learned through my job about Scale Back Alabama, a team weight loss contest that is held annually throughout the state. Teams of four take on the challenge of losing at least 10 pounds per member (40 for the entire team) and have 10 weeks to accomplish their goal. Those who succeed in reaching their goals are eligible for a drawing of prizes.

Inspired, I invited a coworker to join me, and she, in turn, found two more individuals to complete our team. We weighed in at a local site in mid-January of this year and high-fived one another as we departed, determined to give the contest our very best shot. We were subsequently e-mailed weekly lesson plans to help us identify healthy foods to eat and well as physical activities that would best support our weight-loss goals.

I would definitely describe myself as one who has a team spirit, but weight management had previously been a very personal and individual journey for me. However, as my teammates and I exercised together during lunch breaks or after work, ate healthy meals together and swapped diet and exercise tips, I realized how beneficial it can be to make this journey with someone else. We were very honest with each other about our successes and our setbacks, and the support that we gave one another was invaluable.

Today I weighed out with my team and learned that I had lost 13 pounds during the 10-week time frame. Since a healthy weight loss is often described as 1-2 pounds per week, I am pretty proud of myself. This was done without crash dieting, weight loss pills, or enrolling in a for-profit weight loss program (though I do believe that participation in such programs can be helpful).

Not everyone on my team achieved the 10-pound loss, but we all gained something in the process that cannot be measured in numbers. I personally gained the confidence that I have actually moved to a state that is taking some real action in the fight against obesity. While the state health statistics tell part of the story, they do little to show that there are many people in Alabama who genuinely care about their health and are willing to make whatever lifestyle changes they need to bring about positive changes.

As a team, we learned the benefits of group support and bringing at least one other person along on your weight loss journey. We were not disheartened when we learned that collectively, we didn’t achieve the 40-pound weight loss. Instead, we pledged to make this the beginning of a lifelong venture and I have no doubt that this experience will inspire each of us to stick with it in the years to come.